abstract：BACKGROUND:Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial-mesench...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Teraoku H,Morine Y,Ikemoto T,Saito Y,Yamada S,Yoshikawa M,Takasu C,Higashijima J,Imura S,Shimada M

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to examine the diagnostic ability of two-dimensional shear wave elastography (2D-SWE) with propagation-based reliability for grading of hepatic fibrosis and portal hypertension. METHODS:This prospective study (UMIN000022838) consisted of 135 subjects. Phase I (n = 40) examin...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Maruyama H,Kobayashi K,Kiyono S,Sekimoto T,Kanda T,Yokosuka O

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. METHODS:The clinicopathological data of 41 patients who underwent curative resection of AC wer...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Fujimoto T,Ohtsuka T,Date K,Kimura H,Matsunaga T,Mori Y,Miyasaka Y,Mochidome N,Oda Y,Nakamura M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:For the establishment of personalized therapy, we investigated biomarkers that can contribute to the selection of adjuvant therapy for pancreatic ductal adenocarcinoma (PDAC). METHODS:Between 2005 and 2014, of 141 consecutive patients with PDAC who underwent R0 or R1 resection, 61 patients given gemcitabine...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Oba A,Ban D,Kirimura S,Akahoshi K,Mitsunori Y,Matsumura S,Ochiai T,Kudo A,Tanaka S,Minoru T

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Anoikis is a specialized cell apoptosis triggered by loss of cell adhesion. Acquisition of anoikis resistance is a key cancer hallmark that has been associated with metastasis of human malignancies. Cholangiocarcinoma (CCA) is a highly metastatic cancer of the bile duct, in which mechanisms underlying its re...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Huyen NT,Prachayasittikul V,Chan-On W

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Roles of magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), drip infusion cholangiography with computed tomography (DIC-CT), and intraoperative cholangiopancreatography (IOCP) in visualizing pancreaticobiliary anatomy for pediatric choledocal cyst (CC) o...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Saito T,Terui K,Mitsunaga T,Nakata M,Yoshida H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:A total of 26 pancreas transplants from brain dead donors, including 21 simultaneous pancreas and kidney (SPK) transplantation procedures, have been performed at Fujita Health University Hospital since the new pancreas transplant program was initiated in August 2012. The objective of this study is to investi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ito T,Kenmochi T,Ono S,Oshima M,Aida N,Suzuki A,Hasegawa M,Kusaka M,Hoshinaga K

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Recently, a new digital cholangiopancreatoscopy (DCPS) has been developed. The aim of this study is to retrospectively evaluate the utility of new DCPS in patients with pancreaticobiliary diseases. METHODS:Digital cholangiopancreatoscopy was used in 26 patients (16 men) with pancreaticobiliary diseases that...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka R,Itoi T,Honjo M,Tsuchiya T,Kurihara T,Tsuji S,Tonozuka R,Kamada K,Sofuni A,Mukai S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The use of cadaveric vein allografts was first described by our group as a feasible option for venous reconstruction. The aim of this study was to report long-term results of this innovative technique. METHODS:Cold-stored veins harvested from donor cadavers were used as homologous grafts for venous reconstr...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Meniconi RL,Santoro R,Guglielmo N,Vennarecci G,Lepiane P,Colasanti M,Ettorre GM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:We aimed to clarify the appropriate timing for performing percutaneous transhepatic gallbladder drainage (PTGBD) and cholecystectomy, and the effect of PTGBD on surgical difficulty in acute cholecystitis patients. METHODS:We retrospectively examined 46 patients who underwent laparoscopic cholecystectomy (LC...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yamada K,Yamashita Y,Yamada T,Takeno S,Noritomi T

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Two-stage treatment involving stone removal after drainage is recommended for mild to moderate acute cholangitis associated with choledocholithiasis. However, single-stage treatment has some advantages. We aimed to assess the efficacy and safety of single-stage endoscopic treatment for mild to moderate acute...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Eto K,Kawakami H,Haba S,Yamato H,Okuda T,Yane K,Hayashi T,Ehira N,Onodera M,Matsumoto R,Matsubara Y,Takagi T,Sakamoto N,Hokkaido Interventional EUS\/ERCP study (HONEST) group.

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the long-term outcomes and perioperative outcomes of laparoscopic liver resection (LLR) with those of open liver resection (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups. METHODS:Hepatocellular carcinoma patients underwent primary liver rese...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Takahara T,Wakabayashi G,Beppu T,Aihara A,Hasegawa K,Gotohda N,Hatano E,Tanahashi Y,Mizuguchi T,Kamiyama T,Ikeda T,Tanaka S,Taniai N,Baba H,Tanabe M,Kokudo N,Konishi M,Uemoto S,Sugioka A,Hirata K,Taketomi A,Maeh

更新日期：2015-10-01 00:00:00

abstract：:Heterogeneity is one of the essential hallmarks of malignancies. Within bulk cancer cells, a striking variability differs in biological characteristics including the proliferation rate, cell-cell interaction, metastatic tendency and even sensitivity to anticancer therapies. Such diversity makes the investigation and t...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka S

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:An aberrant right posterior sectoral hepatic duct (PHD) draining into extrahepatic bile duct, gallbladder or cystic duct directly is a common and critical anomaly during cholecystectomy. This study aimed to investigate the frequency of aberrant PHD and describe why PHD is critical. METHODS:In 753 consecutiv...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kurata M,Honda G,Okuda Y,Kobayashi S,Sakamoto K,Iwasaki S,Chiba K,Tabata T,Kuruma S,Kamisawa T

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Although intraoperative peritoneal lavage is often performed routinely with the aim of reducing peritoneal contamination, little evidence of lavage benefits in elective liver resection without bile duct resection is available. We addressed the issue with a randomized clinical trial. METHODS:We prospectively...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka K,Matsuo K,Kawaguchi D,Murakami T,Hiroshima Y,Hirano A,Sato S,Endo I,Taguri M,Koda K

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Adequate needle size and tissue acquisition techniques for endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) need further elucidation. Moreover, the actual negative pressure and suction forces of FNA needles remain unknown. We evaluated the suction forces of 19-gauge, 22-gauge, and 25-gauge conve...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Katanuma A,Itoi T,Baron TH,Yasuda I,Kin T,Yane K,Maguchi H,Yamazaki H,Sano I,Minami R,Manabu SY,Ikarashi S,Osanai M,Takahashi K

更新日期：2015-05-01 00:00:00

abstract：:The Milan criteria (MC) have been widely accepted as an effective way of selecting patients with early-stage hepatocellular carcinoma (HCC) for curative liver transplantation (LT). However, since a substantial subset of HCC patients exists that is beyond the MC but with the potential for good outcomes after LT, severa...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Takada Y,Tohyama T,Watanabe J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The effectiveness of prophylactic antibiotics use for acute necrotizing pancreatitis has been explored and a number of systematic reviews have been published with conflicting results. The timing of antibiotics administration can be fundamental to their effectiveness, but thus far no reviews have focused on t...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ukai T,Shikata S,Inoue M,Noguchi Y,Igarashi H,Isaji S,Mayumi T,Yoshida M,Takemura YC

更新日期：2015-04-01 00:00:00

abstract：:Borderline resectable (BR) pancreatic cancer involves the portal vein and/or superior mesenteric vein (PV/SMV), major arteries including the superior mesenteric artery (SMA) or common hepatic artery (CHA), and sometimes includes the involvement of the celiac axis. We herein describe tips and tricks for a surgical tech...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Hirono S,Yamaue H

更新日期：2015-02-01 00:00:00

abstract：:Intrahepatic cholangiocarcinomas (ICCs) are made up of heterogenous carcinomas arising from different anatomical sites of the liver. Two types of candidate stem/progenitor cells of the biliary tree are postulated to exist at the peribiliary glands for large bile ducts and at the canals of Hering for small ducts and he...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Aishima S,Oda Y

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The aim was to examine the diagnostic ability of an endocytoscope system (ECS) for detecting the longitudinal extent of bile duct cancer. METHODS:We observed the surfaces of the bile duct of 28 consecutive patients undergoing biliary surgery both directly and under methylene blue staining by using an ECS. B...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoshikawa T,Hakamada K,Ogasawara H,Kimura N,Kudo D,Sakamoto Y,Ishido K,Toyoki Y,Morohashi S,Kijima H

更新日期：2015-01-01 00:00:00

abstract：:Surgical intervention and, more recently, endoscopic intervention have been performed for the treatment of malignant gastric outlet obstruction. Recently, endoscopic ultrasonography (EUS)-guided gastrojejunostomy using special devices has been established. In line with this, we have developed a novel EUS-guided double...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Ishii K,Tanaka R,Umeda J,Tonozuka R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Whether systemically transplanted human adipose-derived stem cells (ADSCs) homed to the injured liver in nude mice under stress with subsequent hepatectomy (Hx) and ischemia-reperfusion (I/R) was investigated in the present study. The types of cells in the liver that were involved in the homing of ADSCs were...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Saito Y,Shimada M,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Mori H,Arakawa Y,Kanamoto M,Iwahashi S,Takasu C

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:We investigated the aberrant expression of the STAT family in humans and liver fluke (Opisthorchis viverrini, Ov)-induced hamster cholangiocarcinoma (CCA) tissues. METHODS:The expression and phosphorylation of STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b and STAT6 in human hamster CCA tissues were immunohisto...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Dokduang H,Techasen A,Namwat N,Khuntikeo N,Pairojkul C,Murakami Y,Loilome W,Yongvanit P

更新日期：2014-10-01 00:00:00

abstract：:Surgical resection is the only hope for cure in patients with pancreatic cancer. To improve the resectability and achieve better prognosis of this lethal disease, extended resection for pancreatic cancer has been applied. We have performed portal vein resection aggressively for pancreatic cancer with portal vein invas...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoshitomi H,Kato A,Shimizu H,Ohtsuka M,Furukawa K,Takayashiki T,Kuboki S,Takano S,Okamura D,Suzuki D,Sakai N,Kagawa S,Miyazaki M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:This study reviews the outcomes of retransplantation using living-donor right-liver grafts. METHODS:A retrospective study of liver retransplants performed between 1996 and 2013 was conducted. The retransplants were divided into the DD group (with deceased donors) and the LD group (with living donors). Survi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Dai WC,Chan SC,Chok KS,Cheung TT,Sharr WW,Chan AC,Fung JY,Wong TC,Lo CM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Peroral pancreatoscopy (POPS) using a mother-baby endoscope system is often useful for assessment of intraductal papillary mucinous neoplasm (IPMN) of the pancreas with main pancreatic duct (MPD) involvement, but is not widely used for several reasons. The aim of this study was to evaluate the usefulness of ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Nagayoshi Y,Aso T,Ohtsuka T,Kono H,Ideno N,Igarashi H,Takahata S,Oda Y,Ito T,Tanaka M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The study aim was to determine the short- and long-term results of lateral pancreaticojejunostomy for chronic pancreatitis at a single center in Japan. METHODS:The records of 64 consecutive patients were retrospectively reviewed. All patients underwent surgery at Hiroshima University Hospital between Decemb...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sudo T,Murakami Y,Uemura K,Hashimoto Y,Kondo N,Nakagawa N,Sueda T

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The influence of donor-recipient gender mismatch on outcomes after liver transplantation (LT) is controversial. The aim of this study was to evaluate the effect of donor and recipient gender discordance on graft survival. METHODS:All patients who underwent primary LT from 1994-2012 at a single-center were i...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Croome KP,Segal D,Hernandez-Alejandro R,Adams PC,Thomson A,Chandok N

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate our new protocol for performing non-operative management for selected unstable patients under hypotensive resuscitation using improved diagnostic imaging techniques. METHODS:This retrospective study included 77 consecutive patients with blunt liver injury. They we...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Mitsusada M,Nakajima Y,Shirokawa M,Takeda T,Honda H

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Hypoxia is an important condition to promote angiogenesis that is essential to tumor progression, including pancreatic ductal adenocarcinoma (PDAC). We evaluated whether the immunohistochemistry for hypoxia inducible factor-1α (HIF-1α) was correlated with hepatic metastases in PDAC. METHODS:We examined the ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Matsuo Y,Ding Q,Desaki R,Maemura K,Mataki Y,Shinchi H,Natsugoe S,Takao S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Postoperative pancreatic fistula (PF) remains a major complication after pancreaticoduodenectomy (PD). We aimed to investigate the predictors of clinically relevant PF after PD. METHODS:We retrospectively analyzed the predictive factors of relevant grade B/C PF using logistic regression analysis of 100 cons...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kosaka H,Kuroda N,Suzumura K,Asano Y,Okada T,Fujimoto J

更新日期：2014-02-01 00:00:00

abstract：:Advances in the field of minimally invasive surgery have grown since the original advent of conventional multiport laparoscopic surgery. The recent development of single incision laparoscopic surgery remains a relatively novel technique, and has had mixed reviews as to whether it has been associated with lower pain sc...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Qadan M,Curet MJ,Wren SM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Because the biopsy specimen of extrahepatic bile duct carcinoma (EHBDC) is small and shows reactive changes, the histological distinction between malignant and benign tissue can be difficult. Recent studies reported that S100P and insulin-like growth factor II mRNA-binding protein 3 (IMP3) were not only diag...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kawashima H,Itoh A,Ohno E,Miyahara R,Ohmiya N,Tanaka T,Shimoyama Y,Nakamura S,Ebata T,Nagino M,Goto H,Hirooka Y

更新日期：2013-04-01 00:00:00

abstract：:Steady progress is being made in endoscopic biliary intervention, especially endoscopic ultrasonography (EUS)-guided procedures. The EUS-guided rendezvous technique (EUS-RV) is a salvage method for failed selective biliary cannulation. The overall success rate of EUS-RV in 247 cases from seven published articles was 7...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Isayama H,Nakai Y,Kawakubo K,Kawakami H,Itoi T,Yamamoto N,Kogure H,Koike K

更新日期：2013-04-01 00:00:00

abstract：:Enormous efforts have been made to establish pancreatic stem/progenitor cells as a source for regenerative medicine for the treatment of diabetes mellitus. In recent years, it has been recognized that the self-renewal of beta cells is the dominant process involved in postnatal beta-cell regeneration and expansion. Nev...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sekine K,Taniguchi H

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND/PURPOSE:It is generally thought that an internal short stent placed across the pancreaticojejunostomy (PJ) following pancreatoduodenectomy (PD) usually passes spontaneously through the rectum thereafter; however, we experienced some patients who presented with pancreatitis and cholangitis owing to delayed de...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kadowaki S,Miura F,Amano H,Toyota N,Wada K,Shibuya M,Maeno S,Takada T,Sano K

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pan...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ohara H,Okazaki K,Tsubouchi H,Inui K,Kawa S,Kamisawa T,Tazuma S,Uchida K,Hirano K,Yoshida H,Nishino T,Ko SB,Mizuno N,Hamano H,Kanno A,Notohara K,Hasebe O,Nakazawa T,Nakanuma Y,Takikawa H,Research Committee of IgG4

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Isayama H,Sofuni A,Itokawa F,Tamura M,Watanabe Y,Moriyasu F,Kahaleh M,Habib N,Nagao T,Yokoyama T,Kasuya K,Kawakami H

更新日期：2012-09-01 00:00:00